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Sep 02, Pharmaceutical Technology Volume 36, Issue 9 The International Consortium on Innovation and Quality in Pharmaceutical Development IQ formed in is an association of over 25 pharmaceutical and biotechnology companies with a mission to advance science-based and scientifically-driven standards and regulations for medicinal products worldwide. Although more prescriptive guidance is not advocated, the sharing of best practices in this paper is done herein to advance innovation in drug product development by improving cycle times, while maintaining appropriate product quality and ensuring patient safety. A consequence of the absence of clarity surrounding early phase GMP guidance has been varied interpretation and application of existing GMP guidance within different companies and regulatory bodies according to their own culture and risk tolerance. Internal debates often result in conservative “one-size-fits-all” interpretations that rely on International Conference on Harmonization ICH guidelines that are relevant to commercial product development and do not distinguish differences in practices between early development and later-stage development i. A key driver of the IQ WG, therefore, has been to collectively define the minimum acceptable practices within industry regarding GMP expectations in early development that allow for added flexibility and that are consistent with existing guidance and statutes 2, 3. The initial scope of these efforts has been limited to small-molecule development, which support First in Human FIH through Phase 2a proof-of-concept clinical studies. A series of whitepapers describing a recommended approach to applying GMPs in each of these areas is being published within this journal.

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Could not subscribe, try again laterInvalid Email Cheshire East Council has welcomed the news that insurance giant Royal London will remain in the borough and will take up the opportunity to relocate to Alderley Park. The announcement Thursday ends speculation around the future location for the company and means that up to 1, high-skilled jobs will stay in Cheshire East, with the potential to generate far more employment opportunities at its current base in Wilmslow.

The news was announced to staff and management at the Wilmslow site this morning. This includes mixed-use commercial, retail and housing opportunities — subject to planning — which would have the potential to create a further 1, to 2, jobs. Neil Kilshaw, head of group facilities and estate transformation at Royal London, said: Our exhaustive search has convinced us that Cheshire East and Parklands, at Alderley Park, is the best possible location for our business and our staff.

The move is expected to take place before The current Royal London site is a strategic site allocation in the Local Plan. Like us on Facebook.

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Sandbach Crosses There are more than two hundred scheduled monuments in Cheshire , a county in North West England , which date from the Neolithic period to the middle of the 20th century. This list includes the scheduled monuments in Cheshire dating from before the year , the year accepted by Revealing Cheshire’s Past [1] as the start of the Medieval period. A scheduled monument is a nationally important archaeological site or monument which is given legal protection by being placed on a list or “schedule” by the Secretary of State for Culture, Media and Sport ; English Heritage takes the leading role in identifying such sites.

The term “monument” can apply to the whole range of archaeological sites, and they are not always visible above ground.

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The site on the approach into the centre from Macclesfield District General Hospital comprises the grade two-listed main school building, erected in the 19th century and now a library, and another school building dating from the 20th century. Having bought the site for an undisclosed fee, Hillcrest is now proposing to restore the period buildings into luxury apartments, while a number of new-build homes are also planned.

The school gates and a large area of the cricket green fronting the school are proposed to be retained as part of the scheme. The developer is planning to hold a consultation on the plans in autumn this year, with an application to be submitted to Cheshire East Council by the end of Hillcrest managing director James Payne said: It is not in our nature, as a business or individuals, to disregard this heritage. Working with Pick Everard on the designs for the project, the school has already purchased a acre plot off Derby Fields, as well as Fallibroome Farm and its paddocks, which will provide a campus of around 80 acres.

Their plans for the site are very exciting. The terms of the proposal were subject to detailed negotiations with Cheshire East Council and a broad agreement has been reached which meets both the needs of the school and the council in terms of its housing requirements.

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Could not subscribe, try again laterInvalid Email A man raped his own mum during a horrific cocaine-fuelled attack while on bail for raping his girlfriend. The year-old from Wigan blamed his despicable actions on the stress of the accusations from his partner just weeks earlier. He was found guilty of raping his girlfriend in a Liverpool Crown Court trial ending in an extraordinary outburst.

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History[ edit ] The beginnings of Macclesfield Town Football Club can be traced, at least in part, to the 8th Cheshire Rifle Volunteers who were formed in and played regularly in Macclesfield from October It was agreed at a public meeting on 21 October that the 8th Cheshire Rifle Volunteers and the Olympic Cricket club teams be merged to form Macclesfield Football Club: The club played in the FA Cup competition for the first time on 18 November , losing to Lockwood Brothers and entered the Cheshire Senior Cup for the first time in the season, winning this competition for the first time on 22 March when they beat Nantwich and went on to be winners on three more occasions before the turn of the century.

Became members of The Combination at the start of the season and moved from Victoria Road to the Moss Rose on 12 September which remains the home of the Silkmen today. In July the first limited company, Macclesfield Football and Athletic Club Limited, was formed but only lasted until the end of the season when it was wound up and Macclesfield Football Club withdrew from The Combination due to financial constraints.

For the season, and the following two seasons, local amateur side Hallefield moved their fixtures to the Moss Rose. Having re-formed, the Club became members of the Manchester League for the season and were champions in the and seasons. They fielded two senior teams for the season, continuing in the Manchester League with the second team competing in the Lancashire Combination 2nd Division. Having withdrawn from the Manchester League at the end of the season, the club reverted to one senior team for the season which competed in the Lancashire Combination 2nd Division.

They gained promotion as runners-up at the end of the season to compete in the 1st Division for the season. In line with all other football clubs after a decree by the government there was no further competitive football at the Moss Rose during hostilities. Became inaugural members of the Cheshire League at the start of the season of which they were champions in the and seasons. In the season, Albert Valentine set an all-time club record scoring 83 goals in the season.

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Get daily updates directly to your inbox Subscribe Thank you for subscribingWe have more newsletters Show me See our privacy notice Could not subscribe, try again laterInvalid Email The Papers To be successful you have to move with the Times If you’re looking to get your message into the maximum number of households in Macclesfield then look no further, the Macclesfield and Poynton Times is the paper for you! We’re priceless to readers and invaluable to advertisers.

The Market The borough of Macclesfield is located north-east of Cheshire and is home to around , people. The borough is one of the most prosperous parts of the UK with low unemployment, a thriving economy and a well educated workforce.

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Salt is still manufactured at British Salt , which employs around people. The close proximity to the M6 motorway has led to the creation of a large distribution and business park, with companies such as Tesco and ERF locating to the site. Fresh water supply and foul water collection is by United Utilities. Culture and community[ edit ] The Roman theatre in the Bull Ring A highly regarded folk and boat festival has been run in the town every year since , except for when it was cancelled because of a foot and mouth epidemic.

Since its construction this has regularly been used for other purposes, such as an open-air music stage and an ice-rink. Following the Roman festival in , further Roman festivals were held in and Tim Strickland, a consultant archaeologist, was awarded a MBE for services to archaeology for his work in organising the Roman Middlewich Project. A radio station, Cheshire FM , was launched in , covering the mid-Cheshire area including Middlewich — this closed in In a new local radio station was launched, Mid-Cheshire Radio covering Middlewich and the nearby towns of Northwich and Winsford.

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We are internet based as we are frequently roving across the Channel but we are on line every day and always answer our emails speedily and reply to phone messages We offer fully insured FREE delivery for all of our items in Mainland England and Wales The Fancy Fox At The Fancy Fox we offer beautiful and interesting small antiques and collectibles; specialising in fine antique ceramics, both British and continental, and beautiful period silver from Georgian to art deco.

We aim to brighten your life and your home! Prichard Antiques In the heart of the Cotswolds, Prichard Antiques is a High Street shop with 6 showrooms of carefully selected fine and country furniture dating from the 16th to the 20th century.

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